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Storage in ultra-low temperature decreases the levels of IgM anti-cardiolipin antibody in serum samples from Tuberculosis patients

Alexandra Ng, Cheyenne Weeks-Galindo, Amador Goodridge.

Abstract

The evaluation of novel Tuberculosis (TB) biomarkers relies on analysis of previously stored sample sets. We aimed to determine the effect of storage temperature on serum IgM anti-cardiolipin antibody levels in samples from TB patients.  Ultra-low temperature decreased IgM anti-cardiolipin levels. We recommend against using ultra-low temperature storage when investigating IgM anti-cardiolipin biomarker-based tests.

Alexandra Ng, Cheyenne Weeks-Galindo, Amador Goodridge. Therapeutic Advances in Respiratory Diseases , 2014 in press.