Carolina De La Guardia PUBLICACIONES

Molecules 2018, 23(3), 672; doi:10.3390/molecules23030672 (registering DOI)

Antiviral Activity of Novel Quinoline Derivatives against

Dengue Virus Serotype 2.

 Carolina de la Guardia, David E. Stephens, Hang T. Dang, Mario Quijada, Oleg V. Larionov and Ricardo Lleonart.

Abstract:

Dengue virus causes dengue fever, a debilitating disease with an increasing incidence in many tropical and subtropical territories. So far, there are no effective antivirals licensed to treat this virus. Here we describe the synthesis and antiviral activity evaluation of two compounds based on the quinoline scaffold, which has shown potential for the development of molecules with various biological activities. Two of the tested compounds showed dose-dependent inhibition of dengue virus serotype 2 in the low and sub micromolar range. The compounds 1 and 2 were also able to impair the accumulation of the viral envelope glycoprotein in infected cells, while showing no sign of direct virucidal activity and acting possibly through a mechanism involving the early stages of the infection. The results are congruent with previously reported data showing the potential of quinoline derivatives as a promising scaffold for the development of new antivirals against this important virus.

SUSCRÍBETE

Enviando formulario...

El servidor ha detectado un error.

Formulario recibido.

SUSCRÍBETE

Enviando formulario...

El servidor ha detectado un error.

Formulario recibido.

INDICASAT.org.pa

Quienes somos

Síguenos

ISSN 2222-7873

Tel: (507) 5170700 - Fax: (507) 5070020 - EFax: (507) 5170701 | INDICASAT - AIP | Edificio 219, Ciudad del Saber | Clayton, Apartado 0843-01103 | Panamá 5  Panamá, Rep. de Panamá.

 

© Copyright 2014. INDICASAT AIP. Todos los derechos reservados.

Tel: (507) 5170700 - Fax: (507) 5070020 - EFax: (507) 5170701 | INDICASAT - AIP | Edificio 219, Ciudad del Saber | Clayton, Apartado 0843-01103 | Panamá 5  Panamá, Rep. de Panamá.

 

© Copyright 2014. INDICASAT AIP. Todos los derechos reservados.